Generative AI is transforming healthcare, but ensuring safety and reliability remains a critical challenge. We are excited to introduce a groundbreaking approach to AI safety validation called Real World Evaluation of Large Language Models in Healthcare (RWE-LLM), developed by Hippocratical AI. The successful nation-wide implementation of the RWE-LLM framework establishes a practical model for ensuring AI safety in healthcare settings. Our methodology demonstrates that comprehensive output testing provides significantly stronger safety assurance than traditional input validation approaches used by horizontal LLMs.